Chronic inorganic arsenic exposure is mainly through drinking water, whereas exposure to the organic form is most commonly through seafood consumption. Inorganic arsenic, particularly the trivalent methylated species, is more toxic to human health than the organic form ( Chiou et al. The results of this study do not provide clear support for a protective effect of vegetable and overall protein consumption against the development of skin lesions, but a modest benefit cannot be excluded.įrom an international perspective, arsenic exposure is one of the most serious environmental health hazards ( Gebel 2000). Increased intake of beans may be associated with an increased risk of skin lesions. Increased intake of fruit and canned goods may be associated with reduced risk of lesions. Betel nut use appears to be associated with increased risk of developing skin lesions in Bangladesh. Bean intake at least 1 time/day (OR = 1.89 95% CI, 1.11–3.22) was associated with increased odds of skin lesions. Modest decreases in risk of skin lesions were associated with fruit intake 1–3 times/month (OR = 0.68 95%CI, 0.51–0.89) and canned goods at least 1 time/month (OR = 0.41 95% CI, 0.20–0.86). Betel nut use was associated with a greater risk of skin lesions in a multivariate model. Water samples were analyzed for arsenic using inductively coupled plasma mass spectroscopy. Diet, demographic data, and water samples were collected. Six hundred cases and 600 controls loosely matched on age and sex were enrolled at Dhaka Community Hospital, Bangladesh, in 2001–2002. In this study, we evaluated the effect of diet on the risk of arsenic-related skin lesions in Pabna, Bangladesh.
Results of previous studies with limited historical exposure data, and laboratory animal studies suggest that diet may modify arsenic metabolism and toxicity. An established exposure–response relationship exists between water arsenic levels and skin lesions.
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